Aplastic Anaemia- Delving Into The Genes

Aplastic anaemia evolving into myelodysplastic syndrome.

Acquired aplastic anaemia is a clonal disorder of multifactonal origin. The ~pathophysiology of this disorder is still not clear Presumably the multiple incriminating factors include an intrinsic derangement of haematopoiesis, immune mediated damage to bone marrow and genetic predisposition. The long term complications of the aplastic anaemia include clonal evolution into disorders like Paroxys...

Aplastic Anaemia.

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...

Aplastic Anaemia in Children.

A anaemia is a life threatening blood disorder that affects a large number of children each year in India. Exposure to toxic agents like benzene, radiation and viruses like hepatitis A have been implicated in its aetiology. The incidence in developing countries is far higher compared to developed countries. Investigating a child with pancytopenia is more complex than that of an adult as numerou...

Delving into BioMEMS.